Button to universally close emulators?

[JeffBezos]

Does such a Win10 program exist or modification to Win10? Most of my emulators use Escape, but a few have unchangeable obscure buttons/combos.

Sort of like making a new alt+f4 if that makes sense.

[hermine.potter]

You don't need to press the button or combos, that the emulator provides/supports.
If you set an Exit Hotkey (or even a combination of buttons) in AM, AM kills the belonging executable.

for example the NES-emulator Mesen.
If you open a romfile with Mesen and press ESC => Mesen pause the emulation.

if you set ESC as Exit Hotkey in AM:
AM close the complete emulation.

open AM > press TAB-key > Emulators > choose your display > Exit Hotkey : press ESC

[JeffBezos]

You don't need to press the button or combos, that the emulator provides/supports.
If you set an Exit Hotkey (or even a combination of buttons) in AM, AM kills the belonging executable.

for example the NES-emulator Mesen.
If you open a romfile with Mesen and press ESC => Mesen pause the emulation.

if you set ESC as Exit Hotkey in AM:
AM close the complete emulation.

open AM > press TAB-key > Emulators > choose your display > Exit Hotkey : press ESC

How'd I miss that... 

Thank you so much